In a controversial study, which has found widespread resonance among men, it is revealed that male sheep that have undergone castration may live 60% longer than their healthy counterparts.
This is because removal of the testicles delays DNA aging.
Researchers at the University of Otago dropped the trial on men, suggesting that removing their testicles might offer the same benefits.
Epigeneticist Victoria Sogro of the University (Atago) in New Zealand and her colleagues led the study, which has been published in full on eLife. .
The study team said the methods they used could be applied to let farmers know which sheep will live longer, and therefore be more productive.
“Both farmers and scientists have known for some time that neutered male sheep live on average much longer than their healthy counterparts. However, this is the first time anyone has looked at their DNA to see if they are also aging significantly,” Sogru said. slower).
The study team created a so-called animal epigenetic clock, to compare how the DNA progressed in different sheep.
The genetic clock acts as a measure of biological aging based on the presence of chemical markers known as methyl groups.
The team was able to compare the lifespan of a castrated and healthy male once they analyzed a large number of animals in order to calibrate their clock, and found that the epigenetic clocks of castrated sheep ticked slower than that of healthy sheep.
“We’ve developed a way to measure biological age in a wide range of mammals,” says Steve Horvath of the University of California, Los Angeles, the author of the paper and the inventor of the epigenetic clock. “We’ve studied more than 200 species so far and discovered surprising commonalities in how animals age.”
“But the sheep study was unique in that it specifically isolated the effects of male hormones on aging,” he added.
“These findings may help pave the way for new investigations into the mechanisms behind accelerated male aging,” said Tim Hoare, an epigenetic scientist and study leader.
“We found that males and females have very different patterns of DNA aging in sheep,” Tim Hoare said.
Hoare noted that those sites most affected by castration also bind to male hormone receptors in humans at a much greater rate than we would expect, providing a clear link between castration and male hormones and sex-specific differences in DNA aging.
The team then studied mice to explore the effect of male hormones on tissues, and found significant differences between the DNA patterns of male and female mice in tissues.
The study reported that male male hormone receptors are found in mice (as is the case in the skin, brain and kidneys), and they also found that tissues without male hormone receptors tended to be similar in both male and female mice.
This is the first time that scientists have looked at DNA to see if it also ages more slowly.
Women live longer than men
And experts from the World Health Organization have previously announced that the average life expectancy in the world since 2000 has increased by more than five years and is equivalent to 72 years now.
The annual statistical report of the World Health Organization, which was published by the newspaper (Medic Forum), indicated that the average life expectancy in the world began to rise since the beginning of this century, at a rate of 5.5, from 66.5 to 72 years, with an increase in the average lifespan of women compared to men in all regions. .
One of the reasons for the difference in the average age of the sexes is that men rarely visit medical clinics compared to women, according to the report of the international organization.
Lowest review of doctors
In countries where the HIV epidemic is spreading, women visit doctors periodically, and they do the necessary tests to ensure that they are not infected with the disease more than men.
Women make sure they get regular antiviral treatment.
The WHO report notes that men are less likely to see doctors even in cases of diseases that can be detected early, which explains why they are more likely to die.
Other behavioral factors
According to the report, there are behavioral factors that affect the lifespan of men compared to women, as men are more likely to become victims of suicide, homicide and road accidents.
The same report indicated that Prime Time Zone in countries with a low standard of living live 18 years less compared to developed countries.
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