A Swedish study revealed a relationship between the increased use of antibiotics and the risk of colon cancer, indicating that the reason may be the effect of antibiotics on the intestinal microflora.
and published a magazine “Sabir Fifir“The Spanish report that I talked about the incidence of colon cancer, which has increased significantly in recent decades. In fact, factors such as an aging population, diet type and certain habits are some of the reasons why the number of cases is high.
In the report, which was translated by the newspaper “Watan”, the magazine indicated that a large Swedish study confirmed that the use of antibiotics can also increase the risks due to their effect on the gut microbiota.
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It is worth noting that the microbiota helps to develop lymphoid organs and contribute to the strengthening of the intestinal barrier by strengthening blood vessels and the maturation of the epithelial cells that make up their building blocks.
In addition, the microbiota plays an important role in containing inflammatory responses by promoting the growth of a group of specialized lymphocytes, parts of the adaptive immune system whose function is to control and inhibit the immune response, or by calibrating the function of the innate immune system, transforming it from inflammatory to systemic.
The third most common cancer
Colorectal cancer is one of the most common types of colorectal cancer. According to the World Health Organization (OMS), it is ranked third in the world (after lung and breast only) and second in terms of the number of deaths.
Although the causes of most cancers are unknown, we do know that there are various factors that increase the risk of developing the disease, some modifiable and some not.
As stated by the Spanish Society of Medical Oncology (SEOM), the average age of Prime Time Zone who develop this disease is usually between 70 to 71 years and in most cases the age of Prime Time Zone diagnosed is over 50 years old.
Having inflammatory bowel diseases, such as ulcerative colitis or Crohn’s disease.
Your risk of developing colon cancer increases if someone in your family has it. Some inherited genetic mutations also increase the risk.
The typical Western diet, low in fiber and high in fat, has been linked to the development of these tumors. Consumption of red meat and ultra-processed foods has also been indicated as a risk factor in some studies.
- Obesity and a sedentary and routine lifestyle.
- alcohol consumption
- Inactivity and lack of exercise
The composition and function of the gut microbiota is also thought to play a role in the development of this type of cancer. In fact, some of the risk factors we mentioned, such as diet and obesity, are known to disrupt the function of microbes. However, antibiotics may have a greater effect and upset the balance of microorganisms, which encourages the overproduction of certain pathogenic bacteria that may lead to cancer.
In recent years, consumption of antibiotics has grown dramatically. According to one study, between 2000 and 2015, there was a 65 percent increase.
In fact, there has been great concern in the scientific community for a long time about how effective antibiotics can be, as they could be less useful in fighting pathogens.
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To analyze the effect of antibiotic use on colorectal cancer risk, a team of researchers conducted a large study using data extracted from Swedish national registries for the period 2005-2016:
They analyzed 40,545 Prime Time Zone with colorectal cancer and 202,720 Prime Time Zone without the disease. In addition, they obtained data on their use of antibiotics from the Swedish Medicines Registry. Through this information, it was found that the use of antibiotics was associated with a higher incidence of colon cancer.
The risk increases depending on the location of the colon cancer
The researchers also performed sub-analyses, to determine whether the risk was different based on the specific site of the cancer and gender:
Moderate or very high use of antibiotics has been associated with cancer of the proximal colon (ie, located in the first and middle parts of the colon).
No association has been observed between antibiotic use and distal (at the end of the colon) colon cancer.
The association was slightly inverse in the case of rectal cancer, as no differences were observed between men who took antibiotics and those who did not, and there was a slight decrease in the incidence of cancer in women in this region compared to those who took them.
In a related context, researchers noted a consistent association between antibiotic use, and the subsequent increased risk of developing proximal colon cancer and an inverse association with rectal cancer in women. The association between antibiotic use and the risk of proximal colon cancer was also more pronounced among Prime Time Zone aged 50 or older at diagnosis than in those younger than 50.
According to the authors, this study confirms that there is “indirect support for a role for the gut microbiota” in colon cancer.
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